470002 VO Cardiac safety pharmacology (2017W)

Lecture 1 (2.5 hours)- November 15, December 4 2017, 09:00 – 11:30,
Basics of cardiac physiology, electrical and mechanical aspects

Lecture 2 (1.5 hours) – December 6 2017, 09:00 – 10:30,
An introduction in safety pharmacology, a short history, the need of this discipline, test battery, future developments
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/21718297

Lecture 3 (1.5 hours) – December 7 2017, 09:00 – 10:30
Students will present their findings on the development and content of the ISH7b and E14 guidelines, and the CiPA initiative (to be prepared by students, evaluation of content and presentation skills in English)
https://www.ncbi.nlm.nih.gov/pubmed/28986101
https://www.ncbi.nlm.nih.gov/pubmed/25379800

Lecture 4 (1.75 hours)- December 11 2017, 09:00 – 10:45, 2D 358
The cAVB dog model and development of STV as a biomarker, methoxamine rabbit
https://www.ncbi.nlm.nih.gov/pubmed/28574954
https://www.ncbi.nlm.nih.gov/pubmed/25154623
https://www.ncbi.nlm.nih.gov/pubmed/22609158

Lecture 5 (2 hours) – December 12, 2017, 09:00 – 11:00
Target finding. IK1 inhibition by PA-6, development of a new drug? Efficacy and safety
https://www.ncbi.nlm.nih.gov/pubmed/28542844
https://www.ncbi.nlm.nih.gov/pubmed/23625347
https://www.ncbi.nlm.nih.gov/pubmed/22291650
https://www.ncbi.nlm.nih.gov/pubmed/21296684
https://www.ncbi.nlm.nih.gov/pubmed/20180941

Lecture 6 (2 hours) – December 13, 2017, 09:00 – 11:00
Chronic exposure to drugs, the example of ion channel trafficking defects.
https://www.ncbi.nlm.nih.gov/pubmed/18059314
https://www.ncbi.nlm.nih.gov/pubmed/23558293
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/23192368